Enhanced Nasal Deposition and Anti-Coronavirus Effect of Favipiravir-Loaded Mucoadhesive Chitosan-Alginate Nanoparticles

• Main Authors: Khent Primo Alcantara (Author), Nonthaneth Nalinratana (Author), Nopporn Chutiwitoonchai (Author), Agnes L. Castillo (Author), Wijit Banlunara (Author), Opa Vajragupta (Author), Pornchai Rojsitthisak (Author), Pranee Rojsitthisak (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Favipiravir (FVR) is a repurposed antiviral drug for treating mild to moderate cases of the novel coronavirus disease 2019 (COVID-19). However, its poor solubility and permeability limit its clinical efficacy. To overcome its physicochemical and pharmacokinetic limitations, we statistically designed...