Structural Insight into the In Vitro Anti-Intravasative Properties of Flavonoids

• Main Authors: Julia Eichsteininger (Author), Kerstin Kirisits (Author), Claudia Smöch (Author), Christa Stadlbauer (Author), Chi Huu Nguyen (Author), Walter Jäger (Author), Ali Özmen (Author), Gerhard Ecker (Author), Georg Krupitza (Author), Liselotte Krenn (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids in monolayers of lymphendothelial cells. Different representatives of the classes of flavones, flavonols, and flavanones were tested in the c...