Structural Insight into the In Vitro Anti-Intravasative Properties of Flavonoids
We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids in monolayers of lymphendothelial cells. Different representatives of the classes of flavones, flavonols, and flavanones were tested in the c...
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2019-09-01T00:00:00Z.
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| 001 | doaj_9a52568d42d440f4882d85e1b7f9bca9 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Julia Eichsteininger |e author |
| 700 | 1 | 0 | |a Kerstin Kirisits |e author |
| 700 | 1 | 0 | |a Claudia Smöch |e author |
| 700 | 1 | 0 | |a Christa Stadlbauer |e author |
| 700 | 1 | 0 | |a Chi Huu Nguyen |e author |
| 700 | 1 | 0 | |a Walter Jäger |e author |
| 700 | 1 | 0 | |a Ali Özmen |e author |
| 700 | 1 | 0 | |a Gerhard Ecker |e author |
| 700 | 1 | 0 | |a Georg Krupitza |e author |
| 700 | 1 | 0 | |a Liselotte Krenn |e author |
| 245 | 0 | 0 | |a Structural Insight into the In Vitro Anti-Intravasative Properties of Flavonoids |
| 260 | |b MDPI AG, |c 2019-09-01T00:00:00Z. | ||
| 500 | |a 2218-0532 | ||
| 500 | |a 10.3390/scipharm87030023 | ||
| 520 | |a We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids in monolayers of lymphendothelial cells. Different representatives of the classes of flavones, flavonols, and flavanones were tested in the circular chemorepellent-induced defects (CCID)-assay. Bay11-7082, a known inhibitor of CCID formation served as the positive control. This study provides the first comparison of the potential of flavonoids to suppress features influencing the intravasation of MCF-7 breast cancer cells aggregates through the lymph endothelial barrier. The most significant effects were seen after incubation with the flavones luteolin, chrysin, and apigenin. Additional hydroxylation or methoxylation in positions 6 or 8, as expected, resulted in decreased activity. The tested flavanones remained without or low efficacy. | ||
| 546 | |a EN | ||
| 690 | |a CCID assay | ||
| 690 | |a inhibition of gap formation | ||
| 690 | |a flavonoids | ||
| 690 | |a anti-invasive | ||
| 690 | |a breast cancer | ||
| 690 | |a structure-activity relationship | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Scientia Pharmaceutica, Vol 87, Iss 3, p 23 (2019) | |
| 787 | 0 | |n https://www.mdpi.com/2218-0532/87/3/23 | |
| 787 | 0 | |n https://doaj.org/toc/2218-0532 | |
| 856 | 4 | 1 | |u https://doaj.org/article/9a52568d42d440f4882d85e1b7f9bca9 |z Connect to this object online. |