Discovery of novel inhibitors of ghrelin O-acyltransferase enzyme: an in-silico approach

• Main Authors: Faezeh Sadat Hosseini (Author), Alireza Ghassempour (Author), Massoud Amanlou (Author)
• 格式: 图书
• 出版: Wolters Kluwer Medknow Publications, 2022-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Background and purpose: Ghrelin is known as a hunger hormone and plays a pivotal role in appetite, food intake, energy balance, glucose metabolism, and insulin secretion, making it a potential target for the treatment of obesity and type 2 diabetes. The essential maturation step of ghrelin to activa...