Effect of CYP4F2 Polymorphisms on Ticagrelor Pharmacokinetics in Healthy Chinese Volunteers

• Main Authors: Shanshan Nie (Author), Kaifeng Chen (Author), Chengxian Guo (Author), Qi Pei (Author), Chan Zou (Author), Liangyuan Yao (Author), Hongbo Yuan (Author), Xia Zhao (Author), Ran Xie (Author), Xu He (Author), Jie Huang (Author), Guoping Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Ticagrelor belongs to a new class of P2Y12 receptor inhibitor that has been widely used for antiplatelet therapy. This study aimed to explore the effect of single nucleotide polymorphisms (SNPs) in metabolic enzymes, transporters, and other relevant variants on the pharmacokinetics (PK)...