A phase II study of MK-2206, an AKT inhibitor, in uterine serous carcinoma

A phase II study of MK-2206, an AKT inhibitor, in uterine serous carcinoma

Uterine serous carcinoma (USC) is an uncommon subtype of endometrial cancer with a poor prognosis. USCs have genomic alterations in the PI3K pathway. A prior phase II study of AKT inhibitor MK-2206 (an allosteric AKT inhibitor, primarily affecting AKT1 and AKT2) in endometrial cancers resulted in pr...

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Main Authors: Elizabeth H. Stover (Author), Niya Xiong (Author), Andrea P. Myers (Author), Nabihah Tayob (Author), Victoria Engvold (Author), Madeline Polak (Author), Russell R. Broaddus (Author), Vicky Makker (Author), Ronny Drapkin (Author), Joyce F. Liu (Author), Neil S. Horowitz (Author), Funda Meric-Bernstam (Author), Carol Aghajanian (Author), Robert L. Coleman (Author), Gordon B. Mills (Author), Lewis C. Cantley (Author), Ursula A. Matulonis (Author), Shannon N. Westin (Author), Panagiotis A. Konstantinopoulos (Author)
Format: Book
Published: Elsevier, 2022-04-01T00:00:00Z.
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