Photocaging of Pyridinylimidazole-Based Covalent JNK3 Inhibitors Affords Spatiotemporal Control of the Binding Affinity in Live Cells
The concept of photocaging represents a promising approach to acquire spatiotemporal control over molecular bioactivity. To apply this strategy to pyridinylimidazole-based covalent JNK3 inhibitors, we used acrylamido-<i>N</i>-(4-((4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1<i>H...
Saved in:
Main Authors: | Beate Sandra Hoffelner (Author), Stanislav Andreev (Author), Nicole Plank (Author), Pierre Koch (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2023-02-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53
by: Klett T, et al.
Published: (2024) -
Photocaged Histone Deacetylase Inhibitors as Prodrugs in Targeted Cancer Therapy
by: Fabian B. Kraft, et al.
Published: (2023) -
Controlling Antimicrobial Activity of Quinolones Using Visible/NIR Light-Activated BODIPY Photocages
by: Elena Contreras-García, et al.
Published: (2022) -
Covalent DNA Binding Is Essential for Gram-Negative Antibacterial Activity of Broad Spectrum Pyrrolobenzodiazepines
by: Pietro Picconi, et al.
Published: (2022) -
Mapping conformational changes on bispecific antigen-binding biotherapeutic by covalent labeling and mass spectrometry
by: Arnik Shah, et al.
Published: (2024)