Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Preeclampsia (PE) is a rising, potentially lethal complication of pregnancy. PE is driven primarily by the overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1), a validated diagnostic and prognostic marker of the disease when normalized to placental growth factor (PlGF) levels. Inj...

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Main Authors: Sarah M. Davis (Author), Vignesh N. Hariharan (Author), Agnes Lo (Author), Anton A. Turanov (Author), Dimas Echeverria (Author), Jacquelyn Sousa (Author), Nicholas McHugh (Author), Annabelle Biscans (Author), Julia F. Alterman (Author), S. Ananth Karumanchi (Author), Melissa J. Moore (Author), Anastasia Khvorova (Author)
Format: Book
Published: Elsevier, 2022-09-01T00:00:00Z.
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