Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

• Автори: Sarah M. Davis (Автор), Vignesh N. Hariharan (Автор), Agnes Lo (Автор), Anton A. Turanov (Автор), Dimas Echeverria (Автор), Jacquelyn Sousa (Автор), Nicholas McHugh (Автор), Annabelle Biscans (Автор), Julia F. Alterman (Автор), S. Ananth Karumanchi (Автор), Melissa J. Moore (Автор), Anastasia Khvorova (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2022-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Preeclampsia (PE) is a rising, potentially lethal complication of pregnancy. PE is driven primarily by the overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1), a validated diagnostic and prognostic marker of the disease when normalized to placental growth factor (PlGF) levels. Inj...