Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

• Main Authors: Sarah M. Davis (Author), Vignesh N. Hariharan (Author), Agnes Lo (Author), Anton A. Turanov (Author), Dimas Echeverria (Author), Jacquelyn Sousa (Author), Nicholas McHugh (Author), Annabelle Biscans (Author), Julia F. Alterman (Author), S. Ananth Karumanchi (Author), Melissa J. Moore (Author), Anastasia Khvorova (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Preeclampsia (PE) is a rising, potentially lethal complication of pregnancy. PE is driven primarily by the overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1), a validated diagnostic and prognostic marker of the disease when normalized to placental growth factor (PlGF) levels. Inj...