Sodium salicylate rewires hepatic metabolic pathways in obesity and attenuates IL-1β secretion from adipose tissue: The implications for obesity-impaired reverse cholesterol transport

• Main Authors: Sarina Kajani (Author), Sean Curley (Author), Marcella E. O'Reilly (Author), Xiaofei Yin (Author), Eugene T. Dillon (Author), Weili Guo (Author), Kanishka N. Nilaweera (Author), Lorraine Brennan (Author), Helen M. Roche (Author), Fiona C. McGillicuddy (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: High-fat diet (HFD)-induced obesity impairs clearance of cholesterol through the Reverse Cholesterol Transport (RCT) pathway, with downregulation in hepatic expression of cholesterol and bile acid transporters, namely ABCG5/8 and ABCB11, and reduced high-density lipoprotein (HDL) chole...