One-Step Synthesis of Nanoliposomal Copper Diethyldithiocarbamate and Its Assessment for Cancer Therapy

• Main Authors: Radu A. Paun (Author), Daciana C. Dumut (Author), Amanda Centorame (Author), Thusanth Thuraisingam (Author), Marian Hajduch (Author), Martin Mistrik (Author), Petr Dzubak (Author), Juan B. De Sanctis (Author), Danuta Radzioch (Author), Maryam Tabrizian (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The metal complex copper diethyldithiocarbamate (CuET) induces cancer cell death by inhibiting protein degradation and induces proteotoxic stress, making CuET a promising cancer therapeutic. However, no clinical formulation of CuET exists to date as the drug is insoluble in water and exhibits poor b...