Pharmacological Inhibition of PPAR_y Boosts HIV Reactivation and Th17 Effector Functions, while Preventing Progeny Virion Release and <i>de novo</i> Infection

• Main Authors: Delphine Planas (Author), Augustine Fert (Author), Yuwei Zhang (Author), Jean-Philippe Goulet (Author), Jonathan Richard (Author), Andrés Finzi (Author), Maria Julia Ruiz (Author), Laurence Raymond Marchand (Author), Debashree Chatterjee (Author), Huicheng Chen (Author), Tomas Raul Wiche Salinas (Author), Annie Gosselin (Author), Eric A. Cohen (Author), Jean-Pierre Routy (Author), Nicolas Chomont (Author), Petronela Ancuta (Author)
• Format: Book
• Published: Case Western Reserve University, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The frequency and functions of Th17-polarized CCR6+RORyt+CD4+ T cells are rapidly compromised upon HIV infection and are not restored with long-term viral suppressive antiretroviral therapy (ART). In line with this, Th17 cells represent selective HIV-1 infection targets mainly at mucosal sites, with...