Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth

• Main Authors: Tayeba Khan (Author), Hans Weber (Author), Jillian DiMuzio (Author), Andrea Matter (Author), Belma Dogdas (Author), Tosha Shah (Author), Anil Thankappan (Author), Jyoti Disa (Author), Vasant Jadhav (Author), Laura Lubbers (Author), Laura Sepp-Lorenzino (Author), Walter R Strapps (Author), Marija Tadin-Strapps (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Short interfering RNAs (siRNAs) are a valuable tool for gene silencing with applications in both target validation and therapeutics. Many advances have recently been made to improve potency and specificity, and reduce toxicity and immunostimulation. However, siRNA delivery to a variety of tissues re...