Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial Ischemia/Reperfusion Injury

• Main Authors: Christine Herzog (Author), Martina Schmitz (Author), Bodo Levkau (Author), Ilka Herrgott (Author), Jan Mersmann (Author), Jan Larmann (Author), Kai Johanning (Author), Michael Winterhalter (Author), Jerold Chun (Author), Frank Ulrich Müller (Author), Frank Echtermeyer (Author), Reinhard Hildebrand (Author), Gregor Theilmeier (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated sphingophospholipids have similar effects. We therefore examined if HDL-associated sphingosylphosphorylcholine (SPC) reduces infarct size in a mo...