Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum

• Principais autores: Moses N. Ngemenya (Autor), Grace Ntube Abwenzoh (Autor), Hermia Nalova Ikome (Autor), Denis Zofou (Autor), Fidele Ntie-Kang (Autor), Simon M. N. Efange (Autor)
• Formato: Livro
• Publicado em: BMC, 2018-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules. Fourteen synthetic 1, 4-disubstituted piperidines with simple molecular structures were evaluat...