Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles

• Main Authors: Elisa Rojas-Prats (Author), Carlota Tosat-Bitrián (Author), Loreto Martínez-González (Author), Vanesa Nozal (Author), Daniel I. Pérez (Author), Ana Martínez (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2021-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

A potent cell division cycle 7 (CDC7) kinase inhibitor, known as PHA-767491, has been described to reduce the transactive response DNA binding protein of 43 KDa (TDP-43) phosphorylation in vitro and in vivo, which is one of the main proteins found to aggregate and accumulate in the cytoplasm of moto...