Sensitivity to gene dosage and gene expression affects genes with copy number variants observed among neuropsychiatric diseases

• Main Authors: Maria Yamasaki (Author), Takashi Makino (Author), Seik-Soon Khor (Author), Hiromi Toyoda (Author), Taku Miyagawa (Author), Xiaoxi Liu (Author), Hitoshi Kuwabara (Author), Yukiko Kano (Author), Takafumi Shimada (Author), Toshiro Sugiyama (Author), Hisami Nishida (Author), Nagisa Sugaya (Author), Mamoru Tochigi (Author), Takeshi Otowa (Author), Yuji Okazaki (Author), Hisanobu Kaiya (Author), Yoshiya Kawamura (Author), Akinori Miyashita (Author), Ryozo Kuwano (Author), Kiyoto Kasai (Author), Hisashi Tanii (Author), Tsukasa Sasaki (Author), Makoto Honda (Author), Katsushi Tokunaga (Author)
• Format: Knjiga
• Izdano: BMC, 2020-03-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Background Copy number variants (CNVs) have been reported to be associated with diseases, traits, and evolution. However, it is hard to determine which gene should have priority as a target for further functional experiments if a CNV is rare or a singleton. In this study, we attempted to ov...