Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

• Main Authors: Salwa Elmeligie (Author), Asmaa M. Aboul-Magd (Author), Deena S. Lasheen (Author), Tamer M. Ibrahim (Author), Tamer M. Abdelghany (Author), Sohair M. Khojah (Author), Khaled A. M. Abouzid (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (6b, 6e, 7b, 13a, 13c, 16a, 16d and 17a) exhibited ex...