Predicted impact of mass drug administration on the development of protective immunity against Schistosoma haematobium.

• Main Authors: Kate M Mitchell (Author), Francisca Mutapi (Author), Takafira Mduluza (Author), Nicholas Midzi (Author), Nicholas J Savill (Author), Mark E J Woolhouse (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous studies suggest that protective immunity against Schistosoma haematobium is primarily stimulated by antigens from dying worms. Praziquantel treatment kills adult worms, boosting antigen exposure and protective antibody levels. Current schistosomiasis control efforts use repeated mass drug a...