The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE−/− mice by blocking monocyte/macrophage activation

• Main Authors: Florian Kahles (Author), Ana Liberman (Author), Constantin Halim (Author), Matthias Rau (Author), Julia Möllmann (Author), Robert Werner Mertens (Author), Marcia Rückbeil (Author), Irmgard Diepolder (Author), Benedikt Walla (Author), Sebastian Diebold (Author), Mathias Burgmaier (Author), Corinna Lebherz (Author), Nikolaus Marx (Author), Michael Lehrke (Author)
• Format: Book
• Published: Elsevier, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by the gut after food intake leading to pancreatic insulin secretion and glucose lowering. Beyond its role in glucose control, GLP-1 was found in mice and men to beneficia...