The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion

• Main Authors: Qian Chen (Author), Elizabeth Eun Jung Kim (Author), Katrina Elio (Author), Christopher Zambrano (Author), Samuel Krass (Author), Jane Chun-wen Teng (Author), Helen Kay (Author), Kerry-Anne Perkins (Author), Sailesh Pershad (Author), Sloane McGraw (Author), Jeffrey Emrich (Author), Jovan S. Adams (Author), Lindon H. Young (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reduced nitric oxide (NO) bioavailability and increased oxidative stress are major factors mediating ischemia/reperfusion (I/R) injury. Tetrahydrobiopterin (BH4) is an essential cofactor of endothelial NO synthase (eNOS) to produce NO, whereas dihydrobiopterin (BH2) can shift the eNOS product profil...