Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy

• Main Authors: Chuanbin Yang (Author), Chengfu Su (Author), Ashok Iyaswamy (Author), Senthil Kumar Krishnamoorthi (Author), Zhou Zhu (Author), Sichang Yang (Author), Benjamin Chunkit Tong (Author), Jia Liu (Author), Sravan G. Sreenivasmurthy (Author), Xinjie Guan (Author), Yuxuan Kan (Author), Aston Jiaxi Wu (Author), Alexis Shiying Huang (Author), Jieqiong Tan (Author), Kingho Cheung (Author), Juxian Song (Author), Min Li (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD), characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates, is the most common neurodegenerative disorder with limited therapeutic agents. Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates, and tran...