Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS‐1211, a tissue‐nonspecific alkaline phosphatase inhibitor

Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS‐1211, a tissue‐nonspecific alkaline phosphatase inhibitor

Abstract Tissue‐nonspecific alkaline phosphatase (TNAP) hydrolyzes and inactivates inorganic pyrophosphate (PPi), a potent inhibitor of calcification; therefore, TNAP inhibition is a potential target to treat ectopic calcification. These two first‐in‐human studies evaluated safety, tolerability, pha...

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Main Authors: Sonomi Maruyama (Author), Hester Visser (Author), Takashi Ito (Author), Tharin Limsakun (Author), Hamim Zahir (Author), Daniel Ford (Author), Ben Tao (Author), Cynthia A. Zamora (Author), Jeffrey G. Stark (Author), Hubert S. Chou (Author)
Format: Book
Published: Wiley, 2022-04-01T00:00:00Z.
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