Toll-Like Receptor 9 Enhances Bacterial Clearance and Limits Lung Consolidation in Murine Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus

• Main Authors: Anne Jan van der Meer (Author), Achmed Achouiti (Author), Arie van der Ende (Author), Aicha Ait Soussan (Author), Sandrine Florquin (Author), Alex de Vos (Author), Sacha S Zeerleder (Author), Tom van der Poll (Author)
• Format: Book
• Published: BMC, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen in pneumonia associated with severe lung damage. Tissue injury causes release of damage-associated molecular patterns (DAMPs), which may perpetuate inflammation. DNA has been implicated as a DAMP that activates infl...