Development of Nanocrystal Compressed Minitablets for Chronotherapeutic Drug Delivery

• Main Authors: Nagaraja Sreeharsha (Author), Nimbagal Raghavendra Naveen (Author), Posina Anitha (Author), Prakash S. Goudanavar (Author), Sundarapandian Ramkanth (Author), Santosh Fattepur (Author), Mallikarjun Telsang (Author), Mohammed Habeebuddin (Author), Md. Khalid Answer (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present work aimed to develop a chronotherapeutic system of valsartan (VS) using nanocrystal formulation to improve dissolution. VS nanocrystals (VS-NC) were fabricated using modified anti-solvent precipitation by employing a Box-Behnken design to optimize various process variables. Based on the...