The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

• Main Authors: Heather C. Denroche (Author), Michelle M. Kwon (Author), Maria M. Glavas (Author), Eva Tudurí (Author), Marion Philippe (Author), Whitney L. Quong (Author), Timothy J. Kieffer (Author)
• Format: Book
• Published: Elsevier, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Leptin reverses hyperglycemia in rodent models of type 1 diabetes (T1D). Direct application of leptin to the brain can lower blood glucose in diabetic rodents, and can activate autonomic efferents and non-shivering thermogenesis in brown adipose tissue (BAT). We investigated whether lepti...