Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer

• Main Authors: Tyler T. Cooper (Author), Dylan Z. Dieters-Castator (Author), Jiahui Liu (Author), Gabrielle M. Siegers (Author), Desmond Pink (Author), Lorena Veliz (Author), John D. Lewis (Author), François Lagugné-Labarthet (Author), Yangxin Fu (Author), Helen Steed (Author), Gilles A. Lajoie (Author), Lynne-Marie Postovit (Author)
• Format: Book
• Published: BMC, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The five-year prognosis for patients with late-stage high-grade serous carcinoma (HGSC) remains dismal, underscoring the critical need for identifying early-stage biomarkers. This study explores the potential of extracellular vesicles (EVs) circulating in blood, which are believe...