Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer

• Egile Nagusiak: Tyler T. Cooper (Egilea), Dylan Z. Dieters-Castator (Egilea), Jiahui Liu (Egilea), Gabrielle M. Siegers (Egilea), Desmond Pink (Egilea), Lorena Veliz (Egilea), John D. Lewis (Egilea), François Lagugné-Labarthet (Egilea), Yangxin Fu (Egilea), Helen Steed (Egilea), Gilles A. Lajoie (Egilea), Lynne-Marie Postovit (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2024-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background The five-year prognosis for patients with late-stage high-grade serous carcinoma (HGSC) remains dismal, underscoring the critical need for identifying early-stage biomarkers. This study explores the potential of extracellular vesicles (EVs) circulating in blood, which are believe...