Ultrasound-Mediated Blood-Brain Barrier Opening Improves Whole Brain Gene Delivery in Mice

• Main Authors: Marie-Solenne Felix (Author), Emilie Borloz (Author), Khaled Metwally (Author), Ambre Dauba (Author), Benoit Larrat (Author), Valerie Matagne (Author), Yann Ehinger (Author), Laurent Villard (Author), Anthony Novell (Author), Serge Mensah (Author), Jean-Christophe Roux (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene therapy represents a powerful therapeutic tool to treat diseased tissues and provide a durable and effective correction. The central nervous system (CNS) is the target of many gene therapy protocols, but its high complexity makes it one of the most difficult organs to reach, in part due to the...