Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients

• Главные авторы: Johannes Matthaei (Автор), Jürgen Brockmöller (Автор), Werner Steimer (Автор), Konstanze Pischa (Автор), Stefan Leucht (Автор), Maria Kullmann (Автор), Ole Jensen (Автор), Typhaine Ouethy (Автор), Mladen Vassilev Tzvetkov (Автор), Muhammad Rafehi (Автор)
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• Опубликовано: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Предметы: article
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The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics. Apart from interindividual differences in the activity of the metabolising enzymes cytochrome P450 (CYP) 2D6 and 2C19, genetic polymorph...