Feasibility of transdermal transport of atenolol by combination of iontophoresis and oleic acid pretreatment

• Main Authors: Akhmad Kharis Nugroho (Author), Arief Rahman Hakim (Author), Marlyn Dian Laksitorini (Author), Fajar Rakhmatullah (Author), Eny Masruriati (Author)
• Format: Book
• Published: Universitas Gadjah Mada, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atenolol has a low oral bioavailability and a short elimination half-life. Therefore, alternative route and delivery system is important. Transdermal iontophoresis, i.e. a systemic drug delivery via the skin, implementing a low intensity of electrical current, is one attractive candidate. This study...