The human P2X7 receptor alters microglial morphology and cytokine secretion following immunomodulation

• मुख्य लेखकों: Iven-Alex von (लेखक), Jana Martin (लेखक), Manfred Uhr (लेखक), Clemens Ries (लेखक), Jan M. Deussing (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Introduction: In recent years, purinergic signaling via the P2X7 receptor (P2X7R) on microglia has repeatedly been implicated in depression genesis. However, it remains unclear which role the human P2X7R (hP2X7R) plays in regulating both microglia morphology and cytokine secretion upon different env...