Simultaneous quantitation of lamivudine, zidovudine and nevirapine in human plasma by liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study

• Main Authors: Murali Krishna Matta (Author), Nageswara Rao Pilli (Author), Jaswanth Kumar Inamadugu (Author), Laxminarayana Burugula (Author), Seshagiri Rao JVLN (Author)
• Format: Book
• Published: Elsevier, 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A rapid and sensitive LC-MS/MS method for the simultaneous quantitation of lamivudine, zidovudine and nevirapine in human plasma using abacavir as internal standard has been developed and validated. The analytes and IS were extracted from plasma by solid phase extraction using Oasis HLB cartridges a...