Disease-Specific Autoantibodies Induce Trained Immunity in RA Synovial Tissues and Its Gene Signature Correlates with the Response to Clinical Therapy

• Main Authors: Xiaoli Dai (Author), Xiaoqiu Dai (Author), Zheng Gong (Author), Chen Yang (Author), Keqin Zeng (Author), Fang-Yuan Gong (Author), Qiao Zhong (Author), Xiao-Ming Gao (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Much evidence suggests that trained immunity is inappropriately activated in the synovial tissue in rheumatoid arthritis (RA), but the underlying mechanism remains unclear. Here, we describe how RA-specific autoantibody deposits can train human monocytes to exert the hyperactive inflammatory respons...