ABCG2 Single Nucleotide Polymorphism Affects Imatinib Pharmacokinetics in Lower Alpha-1-Acid Glycoprotein Levels in Humans

• Autores principales: Jin-Woo Park (Autor), Hyewon Chung (Autor), Kyoung-Ah Kim (Autor), Jong-Min Kim (Autor), In-Hwan Park (Autor), Sangjin Lee (Autor), Ji-Young Park (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Imatinib is transported extracellularly by ABCB1 and ABCG2 efflux transporters and bound to alpha-1-acid glycoprotein (AGP) in the bloodstream. However, the clinical and pharmacokinetic effects of ABCB1 and ABCG2 on imatinib were inconsistent in the previous literature and have not been confirmed. T...