Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation

• Main Authors: Mengxue Zhang (Author), Jing Li (Author), Qingwei Wang (Author), Go Urabe (Author), Runze Tang (Author), Yitao Huang (Author), Jose Verdezoto Mosquera (Author), K. Craig Kent (Author), Bowen Wang (Author), Clint L. Miller (Author), Lian-Wang Guo (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epigenetically switched, proliferative vascular smooth muscle cells (SMCs) form neointima, engendering stenotic diseases. Histone-3 lysine-27 trimethylation (H3K27me3) and acetylation (H3K27ac) marks are associated with gene repression and activation, respectively. The polycomb protein embryonic ect...