Effect of the novel anti-NGF monoclonal antibody DS002 on the metabolomics of pain mediators, cartilage and bone

• Main Authors: Dandan Jin (Author), Haoyi Yang (Author), Zhiyou Chen (Author), Yuxin Hong (Author), Hehua Ma (Author), Zhenzhen Xu (Author), Bei Cao (Author), Fei Fei (Author), Yuwen Zhang (Author), Weitao Wu (Author), Lei Tang (Author), Runbin Sun (Author), Chunhe Wang (Author), Juan Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The anti-nerve growth factor antibody class of drugs interrupts signaling by blocking NGF binding to TrkA receptors for the treatment of pain; however, this target class of drugs has been associated with serious adverse effects in the joints during clinical trials. DS002 is a novel anti-nerve growth...