Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors

• Hlavní autoři: Farhana Runa (Autor), Gabriela Ortiz-Soto (Autor), Natan Roberto de Barros (Autor), Jonathan A. Kelber (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2024-03-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

SMADs are the canonical intracellular effector proteins of the TGF-β (transforming growth factor-β). SMADs translocate from plasma membrane receptors to the nucleus regulated by many SMAD-interacting proteins through phosphorylation and other post-translational modifications that govern their nucleo...