Structure-Activity Relationship of <i>N</i>-Phenylthieno[2,3-<i>b</i>]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring

Structure-Activity Relationship of <i>N</i>-Phenylthieno[2,3-<i>b</i>]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring

We report synthesis, characterization, biological evaluation, and molecular-docking studies of 18 thieno[2,3-<i>b</i>]pyridines with a phenylacetamide moiety at position 2, which is disubstituted with F, Cl, Br, or I at position 4, and with electron-withdrawing and electron-donating grou...

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Main Authors: César Sebastian Huerta-García (Author), David J. Pérez (Author), Carlos A. Velázquez-Martínez (Author), Seyed Amirhossein Tabatabaei Dakhili (Author), Antonio Romo-Mancillas (Author), Rafael Castillo (Author), Alicia Hernández-Campos (Author)
Format: Book
Published: MDPI AG, 2022-02-01T00:00:00Z.
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