CD3+ B-1a Cells as a Mediator of Disease Progression in Autoimmune-Prone Mice

• Main Authors: Wakako Yamamoto (Author), Hidemi Toyoda (Author), Dong-qing Xu (Author), Ryo Hanaki (Author), Mari Morimoto (Author), Daisuke Nakato (Author), Takahiro Ito (Author), Shotaro Iwamoto (Author), Motoki Bonno (Author), Shigeki Tanaka (Author), Masahiro Hirayama (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

B-1a cells are distinguishable from conventional B cells, which are designated B-2 cells, on the basis of their developmental origin, surface marker expression, and functions. In addition to the unique expression of the CD5 antigen, B-1a cells are characterized by the expression level of CD23. Altho...