Gene Silencing Using 4'-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response

• मुख्य लेखकों: Noriko Tarashima (लेखक), Hidenori Ando (लेखक), Takamitsu Kojima (लेखक), Nozomi Kinjo (लेखक), Yosuke Hashimoto (लेखक), Kazuhiro Furukawa (लेखक), Tatsuhiro Ishida (लेखक), Noriaki Minakawa (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2016-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The development of a versatile technique to induce RNA interference (RNAi) without immune stimulation in vivo is of interest as existing approaches to trigger RNAi, such as small interfering RNA (siRNA) and plasmid DNA (pDNA) expressing short hairpin RNA (shRNA), present drawbacks arising from innat...