A case of congenital autonomous thyroid adenoma with a somatic activating gene mutation in the thyroid-stimulating hormone receptor

• मुख्य लेखकों: Kotaro Tomonaga (लेखक), Kazunori Tahara (लेखक), Toshihiko Watanabe (लेखक), Michinobu Ohno (लेखक), Katsuhiro Ogawa (लेखक), Mai Kutsukake (लेखक), Akihiro Fujino (लेखक), Tomoro Hishiki (लेखक), Kenichi Kinjyo (लेखक), Reiko Horikawa (लेखक), Noriyuki Katsumata (लेखक), Yutaka Kanamori (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2018-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

We report here a male case of autonomous adenoma (AA) in the thyroid that was caused by a somatic heterozygous mutation in the thyroid-stimulating hormone receptor (TSHR) gene at codon 453, which encodes the second transmembrane domain of the protein. This activating mutation of TSHR induced an incr...