Focused Ultrasound-Mediated Delivery of Anti-Programmed Cell Death-Ligand 1 Antibody to the Brain of a Porcine Model

• Main Authors: Siaka Fadera (Author), Chinwendu Chukwu (Author), Andrew H. Stark (Author), Yimei Yue (Author), Lu Xu (Author), Chih-Yen Chien (Author), Jinyun Yuan (Author), Hong Chen (Author)
• Formato: Libro
• Publicado: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Immune checkpoint inhibitor (ICI) therapy has revolutionized cancer treatment by leveraging the body's immune system to combat cancer cells. However, its effectiveness in brain cancer is hindered by the blood-brain barrier (BBB), impeding the delivery of ICIs to brain tumor cells. This study ai...