A novel targeted NGS panel identifies numerous homologous recombination deficiency (HRD)-associated gene mutations in addition to known BRCA mutations

• Κύριοι συγγραφείς: Anne Vogel (Συγγραφέας), Anna Haupts (Συγγραφέας), Michael Kloth (Συγγραφέας), Wilfried Roth (Συγγραφέας), Nils Hartmann (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: BMC, 2024-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Deleterious mutations in the BRCA1 and BRCA2 genes have significant therapeutic relevance in clinical settings regarding personalized therapy approaches. BRCA1 and BRCA2 play a pivotal role in homologous recombination (HR) and thus are sensitive for PARP inhibitors (PARPi). Beyond the narro...