Mutually Isomeric 2- and 4-(3-Nitro-1,2,4-triazol-1-yl)pyrimidines Inspired by an Antimycobacterial Screening Hit: Synthesis and Biological Activity against the ESKAPE Panel of Pathogens

• Main Authors: Sergey Chuprun (Author), Dmitry Dar'in (Author), Elizaveta Rogacheva (Author), Liudmila Kraeva (Author), Oleg Levin (Author), Olga Manicheva (Author), Marine Dogonadze (Author), Tatiana Vinogradova (Author), Olga Bakulina (Author), Mikhail Krasavin (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Starting from the structure of antimycobacterial screening hit OTB-021 which was devoid of activity against ESKAPE pathogens, we designed, synthesized and tested two mutually isomeric series of novel simplified analogs, 2- and 4-(3-nitro-1,2,4-triazol-1-yl)pyrimidines, bearing various amino side cha...