Long‐acting and extended‐release implant and nanoformulations with a synergistic antiretroviral two‐drug combination controls HIV‐1 infection in a humanized mouse model

• Main Authors: Jagadish Beloor (Author), Shalley N. Kudalkar (Author), Gina Buzzelli (Author), Fan Yang (Author), Hanna K. Mandl (Author), Jyothi K. Rajashekar (Author), Krasimir A. Spasov (Author), William L. Jorgensen (Author), W. Mark Saltzman (Author), Karen S. Anderson (Author), Priti Kumar (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The HIV pandemic has affected over 38 million people worldwide with close to 26 million currently accessing antiretroviral therapy (ART). A major challenge in the long‐term treatment of HIV‐1 infection is nonadherence to ART. Long‐acting antiretroviral (LA‐ARV) formulations, that reduce dos...