Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines

• Main Authors: Simon T. Bond (Author), Aowen Zhuang (Author), Christine Yang (Author), Eleanor A.M. Gould (Author), Tim Sikora (Author), Yingying Liu (Author), Ying Fu (Author), Kevin I. Watt (Author), Yanie Tan (Author), Helen Kiriazis (Author), Graeme I. Lancaster (Author), Paul Gregorevic (Author), Darren C. Henstridge (Author), Julie R. McMullen (Author), Peter J. Meikle (Author), Anna C. Calkin (Author), Brian G. Drew (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest for the benefit of both research and therapeutic applications. Whilst many advances have, and continue to be made in this area, perhaps the most utilized technology to date...