Live-attenuated CHIKV vaccine with rearranged genome replicates in vitro and induces immune response in mice.

• Autori principali: Irina Tretyakova (Autore), Joongho Joh (Autore), Mary Gearon (Autore), Jennifer Kraenzle (Autore), Sidney Goedeker (Autore), Ava Pignataro (Autore), Brian Alejandro (Autore), Igor S Lukashevich (Autore), Donghoon Chung (Autore), Peter Pushko (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2024-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Chikungunya fever virus (CHIKV) is a mosquito-borne alphavirus that causes wide-spread human infections and epidemics in Asia, Africa and recently, in the Americas. CHIKV is considered a priority pathogen by CEPI and WHO. Despite recent approval of a live-attenuated CHIKV vaccine, development of add...