Live-attenuated CHIKV vaccine with rearranged genome replicates in vitro and induces immune response in mice.

• Main Authors: Irina Tretyakova (Author), Joongho Joh (Author), Mary Gearon (Author), Jennifer Kraenzle (Author), Sidney Goedeker (Author), Ava Pignataro (Author), Brian Alejandro (Author), Igor S Lukashevich (Author), Donghoon Chung (Author), Peter Pushko (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chikungunya fever virus (CHIKV) is a mosquito-borne alphavirus that causes wide-spread human infections and epidemics in Asia, Africa and recently, in the Americas. CHIKV is considered a priority pathogen by CEPI and WHO. Despite recent approval of a live-attenuated CHIKV vaccine, development of add...