Oxidative Stress and Chronic Myeloid Leukemia: A Balance between ROS-Mediated Pro- and Anti-Apoptotic Effects of Tyrosine Kinase Inhibitors

• Główni autorzy: Alessandro Allegra (Autor), Giuseppe Mirabile (Autor), Santino Caserta (Autor), Fabio Stagno (Autor), Sabina Russo (Autor), Giovanni Pioggia (Autor), Sebastiano Gangemi (Autor)
• Format: Książka
• Wydane: MDPI AG, 2024-04-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The balanced reciprocal translocation t (9; 22) (q34; q11) and the BCR-ABL fusion gene, which produce p210 bcr-abl protein production with high tyrosine kinase activity, are characteristics of chronic myeloid leukemia, a myeloproliferative neoplasm. This aberrant protein affects several signaling pa...