The role of Interleukin-22 in severe acute pancreatitis

Abstract Severe acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a potential systemic inflammatory response that leads to organ failure with increased mortality and a bleak prognosis. Interleukin-22 (IL-22) is a cytokine that may have a...

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Bibliographic Details
Main Authors: Hongli Yang (Author), Ruofan Cao (Author), Feifei Zhou (Author), Ben Wang (Author), Qianqian Xu (Author), Rui Li (Author), ChunHua Zhang (Author), Hongwei Xu (Author)
Format: Book
Published: BMC, 2024-05-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Hongli Yang  |e author 
700 1 0 |a Ruofan Cao  |e author 
700 1 0 |a Feifei Zhou  |e author 
700 1 0 |a Ben Wang  |e author 
700 1 0 |a Qianqian Xu  |e author 
700 1 0 |a Rui Li  |e author 
700 1 0 |a ChunHua Zhang  |e author 
700 1 0 |a Hongwei Xu  |e author 
245 0 0 |a The role of Interleukin-22 in severe acute pancreatitis 
260 |b BMC,   |c 2024-05-01T00:00:00Z. 
500 |a 10.1186/s10020-024-00826-7 
500 |a 1528-3658 
520 |a Abstract Severe acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a potential systemic inflammatory response that leads to organ failure with increased mortality and a bleak prognosis. Interleukin-22 (IL-22) is a cytokine that may have a significant role in SAP. IL-22, a member of the IL-10 cytokine family, has garnered growing interest owing to its potential tissue-protective properties. Recently, emerging research has revealed its specific effects on pancreatic diseases, particularly SAP. This paper provides a review of the latest knowledge on the role of IL-22 and its viability as a therapeutic target in SAP. 
546 |a EN 
690 |a IL -22 
690 |a Sever acute pancreatitis 
690 |a Inflammation 
690 |a Autophagy 
690 |a SAP-induced multiorgan injury 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
690 |a Biochemistry 
690 |a QD415-436 
655 7 |a article  |2 local 
786 0 |n Molecular Medicine, Vol 30, Iss 1, Pp 1-11 (2024) 
787 0 |n https://doi.org/10.1186/s10020-024-00826-7 
787 0 |n https://doaj.org/toc/1528-3658 
856 4 1 |u https://doaj.org/article/9b64dae6efa74cb08d750c1f1cd7710c  |z Connect to this object online.